The pharmaceutical researchers led by Alexandra K. Kiemer are therefore planning a new study to be conducted in collaboration with the sports medicine physician Anne Hecksteden from the research group headed by Professor Tim Meyer at Saarland University. In addition, the formation of muscle fibres is inhibited," says Alexandra K. Kiemer. "We have some evidence that there is a link between statins, physical activity and the GILZ protein, and our plan is to shed more light on how these factors interact with each other," says Professor Kiemer. LDL is just one component of the cardiovascular disease process," he said, adding that just correcting LDL may not be enough to make a difference in the risk of heart disease, stroke and death. "The acronym GILZ stands for glucocorticoid-induced leucine zipper," explains Professor Kiemer. Five reported a reduction in heart attacks and strokes. New study says statins and other cholesterol drugs may not reduce risk of heart disease after all. The information presented on this website is not intended as specific medical advice and is not a substitute for professional medical treatment or diagnosis. Patients who take statins in order to lower their blood cholesterol levels often complain about muscle problems, typically muscle pain. Furthermore, the statins appear to impair the success of physical training programmes. Thank you for taking your time to send in your valued opinion to Science X editors. The precise nature of the bodily processes that induce symptoms of muscle impairment has not yet been fully characterized. Our data indicate that the presence of GILZ in the body can have both positive and negative effects," says Kiemer. Newsmax, Moneynews, Newsmax Health, and Independent. American. August 4, 2020 | Tom Tillison | Print Article. He's a clinical professor of medicine in the division of cardiology at the University of New Mexico's School of Medicine in Albuquerque. However, that's where DuBroff diverges from the American Heart Association and the American College of Cardiology. Total: 408; SHARE 398; TWEET 9; EMAIL 1 … Your opinions are important to us. Hundreds of millions of people worldwide take cholesterol-lowering drugs, like statins, but now a new review suggests that many folks don't benefit from these medications. "According to figures from observational studies, muscle problems have been found to occur in 5% to 29% of cases. Phys.org internet news portal provides the latest news on science, Tech Xplore covers the latest engineering, electronics and technology advances, Science X Network offers the most comprehensive sci-tech news coverage on the web. BBC News provides trusted World and UK news as well as local and regional perspectives. DuBroff said he thinks the guidelines for using cholesterol-lowering medicines may "need to revisit some of this negative or contradictory evidence. While the American Heart Association also emphasizes the importance of a healthy lifestyle, the heart group also recommends that certain people take cholesterol-lowering medications. By William Harwood November 16, 2020 / 7:59 AM / CBS News US Election 2020. The review was published online Aug. 3 in BMJ Evidence-Based Medicine. Generally speaking, statins are well tolerated by patients. By using our site, you acknowledge that you have read and understand our Privacy Policy But, DuBroff added, "Don't be misguided into thinking that you can take a statin and then not pay attention to other risk factors. We tried to objectively look at all of the evidence, not just those studies we favored," DuBroff said. While the latest research first looked at 35 randomized controlled trials of cholesterol-lowering drugs, only 13 of the studies lowered LDL (the "bad" cholesterol) levels enough to be included in the review. The drugs are usually well tolerated and have a low risk of side effects. or, by Saarland University. and Terms of Use. You can unsubscribe at any time and we'll never share your details to third parties. Nasa, Boeing, Bezos and Musk have a lot riding on the US election. Hundreds of millions of people worldwide take cholesterol-lowering drugs, like statins, but now a new review suggests that many folks don't benefit from these medications. They assessed the data in terms of whether statins influenced the production of GILZ in the body. "The main function of GILZ is actually to suppress inflammatory processes in the body. Dr. Donald Lloyd-Jones, president-elect of the American Heart Association (AHA), thinks the latest research relied on questionable studies and remains a proponent of cholesterol-lowering drugs. Of these 13 studies, only one saw a reduced risk of death. Inherited high cholesterol may be common in people with heart disease . Don't underestimate the benefits of lifestyle changes: Keeping body weight at a desired level, eat healthy foods like in the Mediterranean diet, exercise regularly and don't smoke.". Your feedback will go directly to Science X editors. If you have any concerns about your cholesterol medication, both DuBroff and Lloyd-Jones recommended speaking with your doctor. They are also inexpensive. SpaceX launches 4 astronauts to space station, beginning new era for NASA. He noted that most experts agree that LDL cholesterol plays a critical role in the development of plaques that stiffen blood vessels. The latest breaking news, comment and features from The Independent. More information: Jessica Hoppstädter et al, The glucocorticoid‐induced leucine zipper mediates statin‐induced muscle damage, The FASEB Journal (2020… After confirming their original suspicions, the researchers were able to corroborate their hypothesis by carrying out a series of experiments on living cells. If the benefits of lowering cholesterol aren't clear, why are so many people taking these drugs? There also seem to be indications that people who engage in a significant amount of physical activity suffer from muscle problems when prescribed statins. Sep 16, 2020. The research team then tried switching off the GILZ protein in living cells and observing what effect the statins then had. Apart from any fair dealing for the purpose of private study or research, no "This is not like an antibiotic where you can treat for a week and then stop," he said. Click here to sign in with The content is provided for information purposes only. This would suggest that muscle problems may be affecting several hundreds of thousands of patients, potentially as many as 1.8 million, in Germany alone. However, it is not uncommon for patients on statins to complain of muscle pain or muscle weakness. Statins prevent cardiovascular disease not only by lowering blood cholesterol levels, but also by reducing vascular inflammation. They're a huge win for preventive medicine," Lloyd-Jones said. May 29, 2020. "Statins are very effective at lowering LDL cholesterol [preventing it from developing into plaque that deposits on blood vessel walls]. 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The study has been published in The FASEB Journal under the title "The Glucocorticoid-Induced Leucine Zipper Mediates Statin-Induced Muscle Damage.". This document is subject to copyright. "I don't think the review's conclusions are supported by science. The AHA says that high-quality evidence from large randomized controlled trials have shown that statins are effective at bringing LDL levels and heart risks down. "When we look at what happens when statins are administered to muscle cells or entire muscle fibres in which GILZ has been genetically deactivated, the damage that was previously observed is now almost completely absent," says Kiemer. DuBroff said that the researchers found that the degree of reduction in LDL cholesterol didn't have any correlation with decreasing heart attacks, strokes or death. Statins are also very effective at stabilizing the plaque that is already there, and are extremely effective at lowering the risk of heart attacks and strokes. In a recent study, the pharmaceutical scientists Professor Alexandra K. Kiemer und Jessica Hoppstädter from Saarland University have identified a potential causal relationship. Does this mean DuBroff thinks patients should dump their cholesterol-lowering drugs? Visit BBC News for up-to-the-minute news, breaking news, video, audio and feature stories. The latest news on statins Lesley Dobson / 19 September 2017 ... Now statins are in the news again. "Normally, when you have a theory that says something is beneficial, it should be beneficial all the time, but not all of these studies show the benefit," said study author Dr. Robert DuBroff. This, however, leads to impaired muscle function, because increased GILZ production results in an increased rate of muscle cell death. Get weekly and/or daily updates delivered to your inbox. According to the results of their work, statins cause enhanced production of a protein called 'GILZ' that impairs muscle cell function. This site uses cookies to assist with navigation, analyse your use of our services, and provide content from third parties. Support us. The information you enter will appear in your e-mail message and is not retained by Medical Xpress in any form. That's why we thought there might be a connection between statins and GILZ. We do not guarantee individual replies due to extremely high volume of correspondence. A recent study – the longest ever into statins - carried out by scientists at Imperial College, London, and the University of Glasgow, (published in September 2017), produced interesting results. Over the years, her research group has conducted numerous experimental studies into this particular protein. "It's a leap of faith to think that if you lower LDL, it will bring down your cardiovascular risk and mortality. Read Newsmax Terms and Conditions of Service. Links will not be permitted. Categories: Cholesterol | Tags: Cholesterol, Food & Nutrition News, Prevention. Lloyd-Jones said if you have a high risk of heart disease or stroke, it's important not to just stop taking statins and other cholesterol drugs. They believe that a protein known as GILZ is responsible. are registered trademarks of Newsmax Media, Inc. Newsmax TV, and Newsmax World are trademarks of Newsmax Media, Inc. Pa. Judge Opines State's Mail-in Ballot Procedures Likely Illegal... Pennsylvania High Court Rejects Lawsuit Challenging Election... Biden Considering Cindy McCain for UK Ambassador Role... House GOP: Censure Dem for Complaint in Trump Legal Team... Carter Page Suing FBI, DOJ for $75M Over Surveillance... Pa. Judge Opines State's Mail-in Ballot Procedures Likely Illegal, Pennsylvania High Court Rejects Lawsuit Challenging Election, Biden Considering Cindy McCain for UK Ambassador Role, House GOP: Censure Dem for Complaint in Trump Legal Team, Carter Page Suing FBI, DOJ for $75M Over Surveillance. "I think it's a decision between a patient and a provider," he said. Keep discussions on topic, avoid personal attacks and threats of any kind. The researchers said the review of 35 randomized controlled trials failed to show a consistent benefit in lowering the risk of heart attack or stroke, or for preventing deaths. But why this occurs is still largely unresolved. The researchers said the review of 35 randomized controlled trials failed to show a consistent benefit in lowering the risk of heart attack or stroke, or for preventing deaths. , Food & Nutrition News, video, audio and feature stories said he thinks the for. You can unsubscribe at any time and we 'll never share your details to third parties be connection... Ldl, it will bring down your cardiovascular risk and mortality done in the body the bodily processes that symptoms. Address is used only to let the recipient 's address will be used for any other purpose like an where! More comprehensive than those done in the past statins to complain of muscle is. 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